Nolano M, Simone DA, Wendelschafer-Crabb G, Johnson T, Hazen E, Kennedy WR. An update on the treatment of postherpetic neuralgia. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Raja SN, Haythornthwaite JA, Pappagallo M, et al. The middle way: a practical approach to prescribing opioids for chronic pain. Divalproex sodium in the management of post-herpetic neuralgia: a randomized double-blind placebo-controlled study. Pregabalin (lyrica) for neuropathic pain and epilepsy. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. Sabatowski R, Gálvez R, Cherry DA, et al. Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Varicella zoster virus: review of its management. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. Rice AS, Maton S, Postherpetic Neuralgia Study Group. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. EFNS guidelines on pharmacological treatment of neuropathic pain. 2005 2(7):e164.Īttal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS, Nurmikko T. Analgesic therapy in postherpetic neuralgia: a quantitative systematic review. Hempenstall K, Nurmikko TJ, Johnson RW, A’Hern RP, Rice AS. Amitriptyline versus placebo in postherpetic neuralgia. Review of current guidelines on the care of postherpetic neuralgia. Endogenous pain control mechanisms: review and hypothesis. Spinal and trigeminal mechanisms of nociception. Pathophysiology of postherpetic neuralgia: towards a rational treatment. The impact of herpes zoster and post-herpetic neuralgia on quality-of-life. Johnson RW, Bouhassira D, Kassianos G, et al. Triggering of delayed-onset postherpetic neuralgia. Chronic varicella-zoster virus ganglionitis-a possible cause of postherpetic neuralgia. Gilden DH, Cohrs RJ, Hayward AR, Wellish M, Mahalingam R. Post-herpetic neuralgia: post-mortem analysis of a case. Watson CP, Morshead C, Van der Kooy D, et al. Postherpetic neuralgia: are C-nociceptors involved in signaling and maintenance of tactile allodynia? Brain. Post herpetic neuralgia, schwann cell activation and vitamin D. Pathologic features of herpes zoster: a note on “geniculate herpes”. Risk factors for postherpetic neuralgia in patients with herpes zoster. Jung BF, Johnson RW, Griffin DR, Dworkin RH. Herpes zoster: risk categories for persistent pain. Whitley RJ, Weiss HL, Soong SJ, Gnann JW. Herpes zoster and postherpetic neuralgia surveillance using structured electronic data. Klompas M, Kulldorff M, Vilk Y, Bialek SR, Harpaz R. Tontodonati M, Ursini T, Polilli E, Vadini F, Masi F, Volpone D, Parruti G. Prevention of the HZ infection with vaccination is likely the best treatment for PHN. Interventional procedures including sympathetic blocks have been used, but their efficacy is not yet proven. Treatment for PHN is difficult and may require a combination of tricyclic antidepressants, anticonvulsants, opioids, and topical medications. PHN typically is described as a burning sensation along the dermatome affected by the initial HZ infection, often associated with allodynia and anesthesia. Upwards of 17 % of people who develop HZ may ultimately develop PHN. Risk factors for developing PHN are increased age, pain with HZ infection, and severity and duration of symptoms with HZ infection. Post-herpetic neuralgia (PHN) is defined as persistent pain 120 days after resolution of herpes zoster (HZ) acute infection and rash.
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